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Publications (#Corresponding author)

2024

  • Zhang X, Guseinov AA, Jenkins L, Li K, Tikhonova IG#, Milligan G#, Zhang C#. Structural basis for the ligand recognition and signaling of free fatty acid receptors. Science Advances. 2024 Jan 12;10(2):eadj2384. PubMed PMID: 38198545; PubMed Central PMCID: PMC10780892.

2023​​ 

  • Giraldo J, Madsen JJ, Wang X, Wang L, Zhang C, Ye L#. A (19)F-qNMR-Guided Mathematical Model for G Protein-Coupled Receptor Signaling. Molecular Pharmacology. 2023 Dec 15;105(1):54-62. PubMed PMID: 37907352; PubMed Central PMCID: PMC10739436.

  • Zhang X, Weiß T, Cheng MH, Chen S, Ambrosius CK, Czerniak AS, Li K, Feng M#, Bahar I#, Beck-Sickinger AG#, Zhang C#. Structural basis of G protein-Coupled receptor CMKLR1 activation and signaling induced by a chemerin-derived agonist. PLoS Biology. 2023 Dec;21(12):e3002188. PubMed PMID: 38055679; PubMed Central PMCID: PMC10699647.

  • Zhang X, Wang Y, Supekar S, Xu C, Zhou J, Dang J, Chen S, Jenkins L, Marsango S, Li X, Liu G, Milligan G#, Feng M#, Fan H#, Gong W#, Zhang C#. Pro-phagocytic function and structural basis of GPR84 signaling. Nature Communications. 2023 Sep 14. 

2022​ 

  • Serdiuk T, Manna M, Zhang C, Mari S, Kulig W, Pluhackova K, Kobilka BK, Vattulainen I, Müller DJ. A cholesterol analog stabilizes the human β2-adrenergic receptor nonlinearly with temperature. Science Signaling. 2022 June 7; 15(737):eabi7031. PMID: 35671340.

  • Zhuang Y, Wang L, Guo J, Sun D, Wang Y, Liu W, Xu HE#, Zhang C#. Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2. Nature Communications. 2022 Feb 25; 13: 1054. PMID: 35217703.

  • Liu H, Zhang C#. Measuring Smoothened (SMO)-Mediated Activation of the Gi Protein. Methods Mol Biol. 2022; 2374:205-212. PMID: 34562255. 

2021​ 

  • Liu H, Sun D, Myasnikov A, Damian M, Baneres JL, Sun J#, Zhang C#. Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren. Nature Communications. 2021 Nov 11; 12: 6410. PMID: 34737341.

  • Sun D, Sang Z, Kim YJ, Xiang Y, Cohen T, Belford AK, Huet A, Conway JF, Sun J, Taylor DJ, Schneidman-Duhovny D, Zhang C#, Huang W#, Shi Y#. Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes. Nature Communications. 2021 Aug 3;12(1):4676. PubMed: 34344900.

  •  Liu H, Deepak RNVK, Shiriaeva A, Gati C, Batyuk A, Hu H, Weierstall U, Liu W, Wang L, Cherezov V#, Fan H#, Zhang C#.
    Molecular basis for lipid recognition by the prostaglandin D2 receptor CRTH2. Proc Natl Acad Sci U S A. 2021 Aug 10;118(32):e2102813118. PMID: 34341104.

  • Wang L, Xu J, Cao S, Sun D, Liu H, Lu Q, Liu Z, Du Y#, Zhang C#.  Cryo-EM structure of the AVP–vasopressin receptor 2–Gs signaling complex. Cell Research. 2021 Mar 4. PMID: 33664408. 

  • Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL#, Zhang Y#, Zhang C#, Xu HE#. Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell. 2021 Feb 18;184(4):931-942.e18. PubMed PMID: 33571431.

2020​

  • Jang W, Adams CE, Liu H, Zhang C, Levy FO, Andressen KW, Lambert NA. An inactive receptor-G protein complex maintains the dynamic range of agonist-induced signaling. Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30755-30762. PubMed PMID: 33199589.

  • Xiang Y, Nambulli S, Xiao Z, Liu H, Sang Z, Duprex WP, Schneidman-Duhovny D#, Zhang C#, Shi Y#. Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2. Science. 2020 Nov 5; PubMed PMID: 33154108.

  • Dumitru AC, Deepak RNVK, Liu H, Koehler M, Zhang C#, Fan H#, Alsteens D#. Submolecular probing of the complement C5a receptor-ligand binding reveals a cooperative two-site binding mechanism. Communication Biology. 2020 Dec 18;3(1):786. PubMed PMID: 33339958.

  • Xiao Q, Wang L, Supekar S, Shen T, Liu H, Ye F, Huang J, Fan H#, Wei Z#, Zhang C#. Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride. Nature Communications. 2020 Oct 27;11(1):5430. PMID: 33110062.

  • Zhuang Y, Liu H, Zhou E, Kumar Verma R, de Waal P, Jang W, Xu T, Wang L, Meng X, Zhao G, Kang Y, Melcher K, Fan H, Lambert N, Xu HE# and Zhang C#.  Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling.  Nature Communications. 2020 Feb 14;11(1):885. PMID: 32060286.

  • Xing C, Zhuang Y, Xu T, Feng Z, Zhou X, Chen M, Wang L, Meng X, Xue Y, Wang J, Liu H, McGuire T, Zhao G, Melcher K, Zhang C#, Xu HE# and Xie X#.  Cryo-EM structure of the human cannabinoid receptor CB2-Gi signaling complex.  Cell. 2020 Feb 20;180(4):645-654.e13. PMID: 32004460

  • Wendell SG, Fan H#, Zhang C#. G Protein-Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action. Pharmacological Reviews. 2020 Jan;72(1):1-49. Review. PubMed PMID: 31767622.

2019

  • Dutka P, Mukherjee S, Gao X, Kang Y, de Waal PW, Wang L, Zhuang Y, Melcher K, Zhang C, Xu HE, Kossiakoff AA. Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM. Structure. 2019 Oct 23; PubMed PMID: 31669042.

  • Spoerri PM, Sapra KT, Zhang C, Mari SA, Kato HE, Kobilka BK, Müller DJ. Conformational Plasticity of Human Protease-Activated Receptor 1 upon Antagonist- and Agonist-Binding. Structure. 2019 Oct 1;27(10):1517-1526.e3.  PubMed PMID: 31422910.

  • Liu H, Wang D, Zhang Q, Zhao Y, Mamonova T, Wang L, Zhang C, Li S, Friedman PA, Xiao K. Parallel Post-Translational Modification Scanning Enhancing Hydrogen-Deuterium Exchange-Mass Spectrometry Coverage of Key Structural Regions. Analytical Chemistry. 2019 Jun 4;91(11):6976-6980. PMID: 31082219.

  • Qi X, Liu H, Thompson B, McDonald J, Zhang C#, Li X#. Structure of human Smoothened coupled to a heterotrimeric Gi protein. Nature. 2019 Jun 5. PMID: 31168089.

2018

  • Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues J, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C#, Kobilka BK#. Structural insights into binding specificity, efficacy and bias of a beta2AR partial agonist. Nature Chemical Biology. 2018;14(11):1059-66. PMID: 30327561.

  • Wang L, Yao D, Deepak RNVK, Liu H, Xiao Q, Fan H, Gong W, Wei Z#, Zhang C#. Structures of the Human PGD2 Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition. Molecular Cell. 2018 Oct 4;72(1):48-59. PMID: 30220562.

  • Liu H, Kim HR, Deepak RNVK, Wang L, Chung KY, Fan H, Wei Z, Zhang C#. Orthosteric and allosteric action of the C5a receptor antagonists. Nature Structural & Molecular Biology. 2018 Jun;25(6):472-481. PMID: 29867214.

  • Spoerri PM, Kato HE, Pfreundschuh M, Mari SA, Serdiuk T, Thoma J, Sapra KT, Zhang C, Kobilka BK, Müller DJ. Structural Properties of the Human Protease-Activated Receptor 1 Changing by a Strong Antagonist. Structure. 2018 Jun 5;26(6):829-838.e4. PMID: 29731231.

2017 and before (selected)

  • Ju Y, Liu Z, Zhang Z, Duan L, Liu Q, Gu Q, Zhang C, Xu J, Zhou H. Membrane binding of the insertion sequence of Proteus vulgaris L-amino acid deaminase stabilizes protein structure and increases catalytic activity. Sci Rep. 2017;7(1):13719. PMID: 29057984.

  • Pfreundschuh M, Alsteens D, Wieneke R, Zhang C, Coughlin SR, Tampe R, Kobilka BK, Muller DJ. Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM. Nat Commun. 2015;6:8857. PMID: 26561004.

  • Zocher M, Zhang C, Rasmussen SG, Kobilka BK, Muller DJ. Cholesterol increases kinetic, energetic, and mechanical stability of the human beta2-adrenergic receptor. Proc Natl Acad Sci U S A. 2012;109(50):E3463-72. PMID: 23151510.

  • Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK. High-resolution crystal structure of human protease-activated receptor 1. Nature. 2012;492(7429):387-92. PMID: 23222541.

  • Haga K, Kruse AC, Asada H, Yurugi-Kobayashi T, Shiroishi M, Zhang C, Weis WI, Okada T, Kobilka BK, Haga T, Kobayashi T. Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature. 2012;482(7386):547-51. PMID: 22278061.

  • Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, Caffrey M, Gmeiner P, Kobilka BK. Structure and function of an irreversible agonist-beta(2) adrenoceptor complex. Nature. 2011;469(7329):236-40. PMID: 21228876.

  • Zhang C, Liu L, Xu H, Wei Z, Wang Y, Lin Y, Gong W. Crystal structures of human IPP isomerase: new insights into the catalytic mechanism. J Mol Biol. 2007;366(5):1437-46. PMID: 17137593.

  • Li J, Zhang C, Xu X, Wang J, Yu H, Lai R, Gong W. Trypsin inhibitory loop is an excellent lead structure to design serine protease inhibitors and antimicrobial peptides. FASEB J. 2007;21(10):2466-73. PMID: 17384140.

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