Publications (*Corresponding author)

  • Zhuang Y, Liu H, Zhou E, Kumar Verma R, de Waal P, Jang W, Xu T, Wang L, Meng X, Zhao G, Kang Y, Melcher K, Fan H, Lambert N, Xu HE and Zhang C*.  Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling.  Nat Commun. 2020 Feb 14;11(1):885. PMID: 32060286.

  • Xing C, Zhuang Y, Xu T, Feng Z, Zhou X, Chen M, Wang L, Meng X, Xue Y, Wang J, Liu H, McGuire T, Zhao G, Melcher K, Zhang C*, Xu HE* and Xie X*.  Cryo-EM structure of the human cannabinoid receptor CB2-Gi signaling complex.  Cell. 2020 Feb 20;180(4):645-654.e13. PMID: 32004460


  • Dutka P, Mukherjee S, Gao X, Kang Y, de Waal PW, Wang L, Zhuang Y, Melcher K, Zhang C, Xu HE, Kossiakoff AA. Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM. Structure. 2019 Oct 23; PubMed PMID: 31669042.

  • Spoerri PM, Sapra KT, Zhang C, Mari SA, Kato HE, Kobilka BK, Müller DJ. Conformational Plasticity of Human Protease-Activated Receptor 1 upon Antagonist- and Agonist-Binding. Structure. 2019 Oct 1;27(10):1517-1526.e3.  PubMed PMID: 31422910.

  • Liu H, Wang D, Zhang Q, Zhao Y, Mamonova T, Wang L, Zhang C, Li S, Friedman PA, Xiao K. Parallel Post-Translational Modification Scanning Enhancing Hydrogen-Deuterium Exchange-Mass Spectrometry Coverage of Key Structural Regions. Anal Chem. 2019 Jun 4;91(11):6976-6980. PMID: 31082219.

  • Qi X, Liu H, Thompson B, McDonald J, Zhang C*, Li X. Structure of human Smoothened coupled to a heterotrimeric Gi protein. Nature. 2019 Jun 5. PMID: 31168089.


  • Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues J, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C*, Kobilka BK. Structural insights into binding specificity, efficacy and bias of a beta2AR partial agonist. Nat Chem Biol. 2018;14(11):1059-66. PMID: 30327561.

  • Wang L, Yao D, Deepak RNVK, Liu H, Xiao Q, Fan H, Gong W, Wei Z, Zhang C*. Structures of the Human PGD2 Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition. Mol Cell. 2018 Oct 4;72(1):48-59. PMID: 30220562.

  • Liu H, Kim HR, Deepak RNVK, Wang L, Chung KY, Fan H, Wei Z, Zhang C*. Orthosteric and allosteric action of the C5a receptor antagonists. Nat Struct Mol Biol. 2018 Jun;25(6):472-481. PMID: 29867214.

  • Spoerri PM, Kato HE, Pfreundschuh M, Mari SA, Serdiuk T, Thoma J, Sapra KT, Zhang C, Kobilka BK, Müller DJ. Structural Properties of the Human Protease-Activated Receptor 1 Changing by a Strong Antagonist. Structure. 2018 Jun 5;26(6):829-838.e4. PMID: 29731231.

2017 and before (selected)

  • Ju Y, Liu Z, Zhang Z, Duan L, Liu Q, Gu Q, Zhang C, Xu J, Zhou H. Membrane binding of the insertion sequence of Proteus vulgaris L-amino acid deaminase stabilizes protein structure and increases catalytic activity. Sci Rep. 2017;7(1):13719. PMID: 29057984.

  • Pfreundschuh M, Alsteens D, Wieneke R, Zhang C, Coughlin SR, Tampe R, Kobilka BK, Muller DJ. Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM. Nat Commun. 2015;6:8857. PMID: 26561004.

  • Zocher M, Zhang C, Rasmussen SG, Kobilka BK, Muller DJ. Cholesterol increases kinetic, energetic, and mechanical stability of the human beta2-adrenergic receptor. Proc Natl Acad Sci U S A. 2012;109(50):E3463-72. PMID: 23151510.

  • Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK. High-resolution crystal structure of human protease-activated receptor 1. Nature. 2012;492(7429):387-92. PMID: 23222541.

  • Haga K, Kruse AC, Asada H, Yurugi-Kobayashi T, Shiroishi M, Zhang C, Weis WI, Okada T, Kobilka BK, Haga T, Kobayashi T. Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature. 2012;482(7386):547-51. PMID: 22278061.

  • Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, Caffrey M, Gmeiner P, Kobilka BK. Structure and function of an irreversible agonist-beta(2) adrenoceptor complex. Nature. 2011;469(7329):236-40. PMID: 21228876.

  • Zhang C, Liu L, Xu H, Wei Z, Wang Y, Lin Y, Gong W. Crystal structures of human IPP isomerase: new insights into the catalytic mechanism. J Mol Biol. 2007;366(5):1437-46. PMID: 17137593.

  • Li J, Zhang C, Xu X, Wang J, Yu H, Lai R, Gong W. Trypsin inhibitory loop is an excellent lead structure to design serine protease inhibitors and antimicrobial peptides. FASEB J. 2007;21(10):2466-73. PMID: 17384140.

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