Representative membrane protein structures with native ligands, drugs, or drug candidates

Human C5aR with avacopan
(LCP  crystallography)

Human CRTH2 with fevipiprant
(LCP  crystallography)

Human 5alpha-reductase with finasteride
(LCP  crystallography)

Human FPR1 and FPR2-Gi complexes with an N-formyl peptide
(cryo-EM)

Human dopamine D1R-Gs  with apomorphine
(cryo-EM)

Human V2R-Gs with vasopressin
(cryo-EM)

Human ghrelin receptor-Gi complexes with ghrelin and ibutamoren
(cryo-EM)

More to come...