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Representative membrane protein structures with native ligands, drugs, or drug candidates

Screen Shot 2021-07-19 at 8.17.01 PM.png

Human C5aR with avacopan
(LCP  crystallography)

Screen Shot 2021-07-19 at 8.16.17 PM.png

Human CRTH2 with fevipiprant
(LCP  crystallography)

S5A2.tif

Human 5alpha-reductase with finasteride
(LCP  crystallography)

Screen Shot 2021-07-19 at 8.14.24 PM.png

Human FPR1 and FPR2-Gi complexes with an N-formyl peptide
(cryo-EM)

Screen Shot 2021-07-19 at 8.38.52 PM.png

Human dopamine D1R-Gs  with apomorphine
(cryo-EM)

Screen Shot 2021-07-19 at 8.30.12 PM.png

Human V2R-Gs with vasopressin
(cryo-EM)

Screen Shot 2021-07-19 at 8.37.37 PM.png

Human ghrelin receptor-Gi complexes with ghrelin and ibutamoren
(cryo-EM)

Screen Shot 2023-09-15 at 4.37.08 PM.png
Screen Shot 2023-09-15 at 4.37.38 PM.png

Human free fatty acid receptor signaling complexes
(cryo-EM)

More to come... 

©2020 by University of Pittsburgh.

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